Novel delivery system with a dual–trigger release of savory essential oil by mesoporous silica nanospheres and its possible targets in leukemia cancer cells: in vitro study

Abstract Introduction Essential oils (EOs) are complex structures and possess several pharmacological effects. Nanomedicine offers a solution for their major limitations, including poor solubility, volatility, non–controlled release, preventing clinical use. Methods Here, we developed novel delivery system by nanoformulations that were prepared impregnating savory essential oil (SA) into mesoporous silica nanoparticles (MSNs). The characterized examined anticancer activities on cancer cells (HepG2 liver HL60 leukemia cells) MRC5 normal cells. We further tested the mechanisms of action possible molecular targets against Results results demonstrated SA was governed under dual–trigger release pH/glutathione, it typically fit Korsmeyer–Peppas kinetic model. enhanced effect HepG2 compared to but less cytotoxic regulated various pathways apoptosis. Most importantly, new obtained genetic regulation principle through high inhibition long noncoding RNAs (HOTAIR, HULC, CCAT1, H19) matrix metalloproteinases (MMP–2 MMP–9), providing target. Conclusions These suggest potential impacts composed with sustained pattern controlled pH/GSH This approach may offer route using EOs as cancers open door deep preclinical investigations.